D2 NO GAMMA CONTROL CODE

All other relevant data are within the paper and its Supporting Information files.ДЇunding: This work was funded by National Science Foundation Division of Mathematical Sciences ( ) grant DMS-1514796 (PI: NJK) and National Institute of Mental Health ( ) grant 1R01MH114877-01 (PI: NJK). A persistent copy of the model is also available at ModelDB as 'Striatal FSI and SPN oscillation model (Chartove et al.

D2 NO GAMMA CONTROL CODE

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Дata Availability: All code used to generate the simulations and figures in this manuscript is available at. Received: JAccepted: DecemPublished: February 25, 2020Д¬opyright: В© 2020 Chartove et al. We hypothesize that high dopamine-induced periodic FSI Оі-rhythmic inhibition enables switching between ОІ-rhythmic SPN cell assemblies representing the currently active motor program, and thus that dopamine facilitates movement in part by allowing for rapid, periodic shifts in motor program execution.Д¬itation: Chartove JAK, McCarthy MM, Pittman-Polletta BR, Kopell NJ (2020) A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control. In addition to a mechanistic explanation for previously observed rhythmic interactions and transitions, our model suggests a hypothesis as to how the relationship between dopamine and rhythmicity impacts motor function. Thus, in the high dopamine state, packets of FSI Оі and SPN ОІ alternate at a Оґ/ Оё timescale. SPN networks produce ОІ rhythms in both conditions, but under high dopaminergic tone, this ОІ oscillation is interrupted by Оґ/ Оё-periodic bursts of Оі-frequency FSI inhibition. Under simulated low dopaminergic tone our model FSI network produces low Оі band oscillations, while under high dopaminergic tone the FSI network produces high Оі band activity nested within a Оґ/ Оё oscillation.

Building on previous modeling and experimental work suggesting that striatal projection neurons (SPNs) are capable of generating ОІ oscillations, we show that networks of striatal fast-spiking interneurons (FSIs) are capable of generating Оґ/ Оё (ie, 2 to 6 Hz) and Оі rhythms. In this paper, we propose a biophysical model of striatal microcircuits that comprehensively describes the generation and interaction of these rhythms, as well as their modulation by dopamine.

The mechanisms underlying these rhythmic dynamics, their interactions, and their functional consequences are not well understood. Local field potential recordings in rodent striatum show dopamine- and reward-dependent transitions between two states: a вЂњspontaneousвЂќ state involving ОІ (в€ј15-30 Hz) and low Оі (в€ј40-60 Hz), and a state involving Оё (в€ј4-8 Hz) and high Оі (в€ј60-100 Hz) in response to dopaminergic agonism and reward. Striatal oscillatory activity is associated with movement, reward, and decision-making, and observed in several interacting frequency bands.

D2 no gamma control